Butyrate and Allulose: The Two Ingredients Behind Ozzi (2026)

By Brandon, founder of Ozzi · Published August 20, 2026

Ozzi Crave Crusher uses 8g of allulose as a sweetener with a minimal glycemic footprint, and 500mg of BIOMEnd L-Lysine Butyrate as a postbiotic short-chain fatty acid. Allulose is largely absorbed in the small intestine and is not a prebiotic. Butyrate is the primary energy source for colon cells.

Most supplements in this category read like a shopping list. Twenty-two ingredients, most of them at doses too low to do anything, all of them there so the label looks generous.

We went the other way. Two ingredients carry the product, and I can tell you exactly what each one is for and exactly what it isn't.

Why two hero ingredients instead of fifteen?

Because the problem people actually come to us with has two separate halves, and they need separate answers.

Read enough customer surveys and the pattern is unmistakable. It's not "I'm hungry." It's "I ate a huge dinner at 9 and I was snacking again at 10:30." It's "I'm not even hungry but the urge to eat is so overwhelming that I do it anyway."

That's two problems stacked. There's a want for something sweet that doesn't care whether you've eaten. And there's whatever is going on in the gut and the signalling around it that makes appetite feel disconnected from actual need.

One ingredient can't address both. So we picked one for each.

Two ingredients you can defend beats twenty you have to hide behind a proprietary blend.

What is allulose actually doing?

8g per stick, the largest ingredient by weight. Its job is sweetness without the metabolic cost, and it's genuinely good at that one job.

Allulose is a rare sugar. It tastes close to sucrose but your body handles it completely differently. In a human study measuring urinary excretion over 48 hours, roughly 70% of an ingested dose came back out in urine unchanged across three dose levels. The same team measured breath hydrogen, the standard test for bacterial fermentation, and allulose barely registered next to a known fermentable fiber control.¹

They also found it wasn't being metabolized for energy. Carbohydrate energy expenditure didn't rise in the 3 hours after a dose, and they put its energy value at under 1.6 kJ per gram against sugar's roughly 16.¹

So: sweet on the tongue, absorbed in the small intestine, out through your kidneys, minimal glycemic footprint. That's the whole pitch and it's a good one. Details in does allulose spike blood sugar and is allulose safe.

What allulose is not doing

It is not feeding your gut bacteria, and we don't claim it does.

A 12-week randomized, double-blind, placebo-controlled trial gave adults 15g of allulose per day and sequenced stool before and after with shotgun metagenomics. No shift in microbial diversity. No change in short-chain fatty acid production. No pathogen bloom either, which is a good safety result and a completely flat prebiotic result.²

There's a clean mechanistic reason. Gut bacteria need an enzyme called AlsE to use allulose as a carbon source, and when researchers searched 3,079 healthy adult human gut metagenomes, the gene showed up in only 15.8% of samples.³

Most people's bacteria can't eat it. That's precisely why it's gentler on the stomach than sugar alcohols, and precisely why it does nothing prebiotic. You don't get both.

If you see allulose sold as a gut health ingredient, that's the claim to push back on. The long version is in allulose and gut health.

What is BIOMEnd butyrate doing?

500mg per stick, and this is the gut half of the formula.

Butyrate is a short-chain fatty acid your gut bacteria produce when they ferment fiber. It's the primary energy source for the cells lining your colon, which burn it in preference to glucose.⁴ It also acts as a histone deacetylase inhibitor, a well-characterized mechanism.⁵

We use it as a postbiotic, meaning we're supplying the finished compound rather than the bacteria or the fiber that would eventually make it.

The specific form is L-Lysine Butyrate, sold as BIOMEnd. In the only published head-to-head human trial, it reached peak blood concentration at 20 minutes in every participant, roughly 5x higher than tributyrin and 31 minutes sooner.⁶ It also carries no sodium and rated most palatable in organoleptic testing, which matters a great deal for something you drink daily. Full reasoning in why we picked BIOMEnd.

What butyrate is not doing

Same honesty applies here, and it costs us more.

The link between butyrate and GLP-1 release is a proposed mechanism mapped in mice and cell cultures, not a human finding.⁷ A human trial that successfully raised circulating butyrate measured GLP-1 as a named secondary outcome and found no change.⁸

The appetite suppression findings are from mice.⁹ The insulin sensitivity findings are from mice. And there are zero clinical outcome trials on lysine butyrate specifically.

We sell this as a GLP-1 support product and I'm still telling you that. The mechanism is promising and preclinical. Anyone framing it as established human science is ahead of the evidence. Full audit in butyrate benefits, hype, and downsides.

So how do the two work together?

They mostly don't, and that's the point.

This is where most brands invent a synergy story. There isn't one here. Allulose does not enhance butyrate absorption. Butyrate does not change how allulose is metabolized. They're two independent tools aimed at two independent problems, sharing a stick pack.

If there's a connecting thread it's not between those two. It's the chicory root inulin sitting alongside them at 500mg. That's the prebiotic fiber, and it's the one with human randomized trial data for actually shifting bacteria: in a placebo-controlled crossover trial in 50 adults, 7g per day of chicory inulin-type fructans raised relative Bifidobacterium abundance from 5.3% to 18.7% over 4 weeks.¹⁰

Inulin feeds the bacteria that make butyrate. BIOMEnd delivers butyrate directly. Those two genuinely are two ends of the same pathway. Allulose is off doing something else entirely, which is fine, because that something else is what makes the drink worth putting in your mouth.

What about the rest of the formula?

Five more actives, each with a narrow job:

• Glucomannan, 500mg. A viscous fiber from konjac root that absorbs water and expands in the stomach. Its lane is physical fullness, nothing more. It carries an FDA-recognized structure/function claim for appetite support.
• Chicory root inulin, 500mg. The prebiotic, covered above.
• African mango extract, 150mg. Research on Irvingia gabonensis suggests effects on body weight and metabolic markers, mostly from a small set of trials.
• Chromium as Metabolex, 11mg. An essential trace mineral with a long-established role in insulin signalling. Supports blood sugar control.

No caffeine. No stimulants. No berberine. No artificial sweeteners. Vegan. The full ingredient breakdown lives on the Crave Crusher page.

Why we round the doses down

Small thing that matters. Every dose we publish is rounded down from what's actually in the stick, never up.

The formula sheet says 8.35g of allulose. We print 8g. It says 537mg of L-Lysine Butyrate. We print 500mg. Same with glucomannan.

The reason is boring and deliberate: no label check, no batch variance, and no skeptical thread on Reddit can ever catch our marketing claiming more than the stick contains. If we're going to be wrong, we'd rather be wrong in the direction that costs us.

References

1. Iida T, Kishimoto Y, Yoshikawa Y, et al. Failure of D-psicose absorbed in the small intestine to metabolize into energy and its low large intestinal fermentability in humans. Metabolism. 2010;59(2):206-14. Human. https://doi.org/10.1016/j.metabol.2009.07.018
2. Impact of D-allulose consumption on enteric pathogens in human gut microbiota: a randomized controlled trial study. Journal of Functional Foods. 2024;122:106555. Human RCT. https://doi.org/10.1016/j.jff.2024.106555
3. Ndjite GM, et al. Gut microbial utilization of the alternative sweetener, D-allulose, via AlsE. Communications Biology. 2025;8(1):970. Bioinformatic and in-vitro. https://doi.org/10.1038/s42003-025-08391-3
4. Donohoe DR, Garge N, Zhang X, et al. The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon. Cell Metabolism. 2011;13(5):517-526. https://doi.org/10.1016/j.cmet.2011.02.018
5. Davie JR. Inhibition of Histone Deacetylase Activity by Butyrate. The Journal of Nutrition. 2003;133(7):2485S-2493S. https://doi.org/10.1093/jn/133.7.2485S
6. La Monica MB, Kirby T, Hartshorn SL, Gustat A, Grdic J, Sandrock J. A Pharmacokinetic Comparison of Three Butyrate Products. Journal of Exercise and Nutrition. 2025;8(1):4. Human randomized crossover trial, n=10. NCT06700785. Full text (open access)
7. Tolhurst G, Heffron H, Lam YS, et al. Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2. Diabetes. 2012;61(2):364-371. Mouse and cell culture. https://doi.org/10.2337/db11-1019
8. van Deuren T, Smolders L, Hartog A, et al. Butyrate and hexanoate-enriched triglycerides increase postprandial systemic butyrate and hexanoate in men with overweight/obesity: A double-blind placebo-controlled randomized crossover trial. Frontiers in Nutrition. 2023;9:1066950. Human RCT. https://doi.org/10.3389/fnut.2022.1066950
9. Li Z, Yi CX, Katiraei S, et al. Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit. Gut. 2018;67(7):1269-1279. Mouse. https://doi.org/10.1136/gutjnl-2017-314050
10. Reimer RA, Soto-Vaca A, Nicolucci AC, et al. Effect of chicory inulin-type fructan-containing snack bars on the human gut microbiota in low dietary fiber consumers in a randomized crossover trial. American Journal of Clinical Nutrition. 2020;111(6):1286-1296. Human RCT. https://doi.org/10.1093/ajcn/nqaa074
11. Han Y, Kwon EY, Yu MK, Lee SJ, Kim HJ, Kim SB, Kim YH, Choi MS. Gastrointestinal tolerance of D-allulose in healthy and young adults: a non-randomized controlled trial. Nutrients. 2018;10(12):2010. Human. https://doi.org/10.3390/nu10122010
12. Daniel H, Hauner H, Hornef M, Clavel T. Allulose in human diet: the knowns and the unknowns. British Journal of Nutrition. 2022;128(2):172-178. Review. https://doi.org/10.1017/S0007114521003172

Peer-reviewed sources retrieved via PubMed. General information, not medical advice. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.