What's In Ozzi
(And Why It Works)
Every Ozzi Crave Crusher stick pack is built around six clinically studied ingredients designed to support GLP-1 production, appetite control, blood sugar balance, and fat metabolism. No proprietary blends. No hidden doses.
Tap any ingredient card below to jump to the full breakdown, including mechanism of action, peer-reviewed human research, and why we landed on the dose we chose.
Built on the GLP-1 pathway,
Naturally
The first postbiotic GLP-1 support drink stick. Patented BIOMEnd butyrate and 8g of allSWEET allulose support your body's GLP-1 response, backed by 4 more clinically studied ingredients targeting satiety, blood sugar, and fat metabolism.
allSWEET Allulose: 8g
BIOMEnd Butyrate: 500mg
A patented postbiotic form of butyrate bound to L-lysine. Peer-reviewed research shows butyrate stimulates GLP-1 and PYY release from intestinal L-cells (the same satiety hormones your body makes naturally), while also strengthening gut barrier integrity.*
Metabolex Chromium: 300mcg
A patented form of chromium bound to ursolic acid. Chromium is one of the most researched minerals for insulin sensitivity, helping your cells respond to insulin more efficiently so glucose gets used instead of stored, which supports steady energy and fewer carb cravings.*
Konjac Root: 500mg
A soluble fiber from the konjac plant that expands up to 50 times its weight in water, creating physical fullness in the stomach while slowing carbohydrate absorption. Konjac also supports healthy blood sugar and cholesterol levels.*
African Mango Extract: 150mg
Extracted from Irvingia gabonensis seeds, African mango is clinically studied for supporting healthy body weight, waist circumference, and leptin signaling (the hormone that tells your brain you're full so you stop eating).*
Ursolic Acid: 10mg
A bioavailable form of ursolic acid delivered as Metabolex (bound to chromium). Found naturally in apple peels and rosemary, ursolic acid is anti-inflammatory and helps your body protect lean muscle during weight loss so your metabolism stays strong.*
Take control of your cravings
Naturally
Ozzi is formulated using 6 Clinically Studied ingredients that can help reduce hunger hormones.
How These 6 Ingredients Work Together
Appetite isn't controlled by one pathway. It runs across a network of overlapping signals: hormones like GLP-1, PYY, CCK, and leptin, plus blood sugar, gut bacteria, stretch receptors, and nerve signals from the gut to the brain.
Ozzi was built to support that full network instead of any single pathway. Allulose activates sweet taste receptors in the gut to release satiety hormones. BIOMEnd butyrate stimulates L-cells directly. Konjac creates physical fullness and slows carb absorption. Chromium supports insulin sensitivity. Ursolic acid activates AMPK for fat metabolism. African mango supports leptin signaling. Each ingredient has a job, and nobody is trying to carry the whole load alone.
A small amount of chicory root inulin (500mg) is included as a supporting prebiotic fiber to complement konjac and feed beneficial gut bacteria. It's a supporting player in the formula, not one of the six clinically studied actives.
allSWEET Allulose | 8g per serving
What it is
Allulose (also called D-allulose or D-psicose) is a rare sugar that occurs naturally in figs, raisins, maple syrup, and wheat. It tastes almost identical to table sugar but has about 90% fewer calories and doesn't raise blood sugar or insulin.
We use allSWEET, a high-purity allulose sourced from non-GMO corn.
How it works
Allulose activates the T1R2/T1R3 sweet taste receptors in your gut without being absorbed and metabolized like sugar. That activation alone is enough to tell your intestines to release GLP-1, CCK, and PYY, the three biggest satiety hormones your body makes on its own.
What the research shows
1. Allulose directly stimulates GLP-1 release in humans. A 2022 randomized controlled trial in the Journal of Nutrition showed that oral allulose activated the gut sweet taste receptor and stimulated GLP-1 secretion in humans, with downstream effects on satiety and postprandial glucose. This is the cleanest human receipt on the allulose-to-GLP-1 link. (Teysseire et al., 2022, J Nutr)
2. Allulose triggers GLP-1 release through vagal nerve activation. A landmark 2018 paper in Nature Communications established that D-allulose induces GLP-1 release and activates vagal afferent nerves, linking the gut signal to the brain. The study tied these effects to improved glucose tolerance and appetite control. (Iwasaki et al., 2018, Nat Commun)
3. Meta-analysis confirms allulose lowers postprandial blood glucose. A 2023 systematic review and meta-analysis in PLOS One pooled human trials on allulose and found a significant reduction in postprandial blood glucose levels in healthy adults, without the insulin spike you'd see from regular sugar. (Braunstein et al., 2023, PLOS One)
Allulose has been studied in dozens of human trials covering glycemic response, insulin sensitivity, and safety at doses up to 25g per serving. The three studies above are the tightest receipts on the GLP-1 and blood sugar side.
Why 8g
Research shows the satiety and glucose effects of allulose kick in around 5g and scale up from there. 8g is a practical daily dose that fits comfortably in a stick pack, tastes clean, and sits within the range studied in the peer-reviewed literature. It's enough to do the work without overdosing sweetness.
BIOMEnd L-Lysine Butyrate | 500mg per serving
What it is
Butyrate is a short-chain fatty acid that your gut bacteria produce when they ferment fiber. It's the primary fuel for the cells lining your colon and one of the most important molecules for gut health.
The catch is that straight butyrate is unstable, smells awful, and doesn't survive the trip through your digestive tract. BIOMEnd is a patented postbiotic form of butyrate bound to the amino acid L-lysine, which protects it until it reaches the intestine where it can do its job. This is why you can drink Ozzi without the notorious butyrate smell.
How it works
Butyrate stimulates the L-cells in your small intestine to release GLP-1 and PYY, the same satiety hormones that prescription GLP-1 drugs mimic. It also feeds the cells of your gut lining, which supports healthy gut barrier function and reduces low-grade inflammation.
What the research shows
1. Butyrate directly triggers GLP-1 release from intestinal L-cells. A landmark 2013 paper in the Journal of Biological Chemistry demonstrated that butyrate induces GLP-1 secretion from human L-cells, with downstream effects on insulin sensitivity and glucose tolerance. This is the foundational mechanism paper behind butyrate's role in the GLP-1 pathway. (Yadav et al., 2013, J Biol Chem)
2. Butyrate supplementation raised postprandial GLP-1 in people with type 2 diabetes. A randomized, double-blind, placebo-controlled clinical trial in adults with type 2 diabetes found that oral butyrate supplementation significantly increased postprandial GLP-1 concentrations and showed favorable trends in HOMA-IR, a marker of insulin resistance. This is the human RCT that validates the mechanism in a real clinical population. (Roshanravan et al., 2017, Horm Metab Res)
3. Butyrate boosted PYY and fat oxidation in overweight humans. In a randomized controlled study, colonic infusion of short-chain fatty acid mixtures high in butyrate significantly increased fasting and postprandial PYY (the satiety hormone that works alongside GLP-1) and acutely raised fat oxidation in overweight and obese men. (Canfora et al., 2017, Sci Rep)
Butyrate is one of the most studied short-chain fatty acids in metabolic research, with dozens of additional papers covering gut barrier integrity, insulin sensitivity, and the gut-brain axis. The three studies above are the clearest receipts on butyrate's role in GLP-1 and satiety hormone signaling.
Why 500mg
500mg of BIOMEnd delivers a meaningful dose of bioavailable butyrate without overwhelming the stick pack or creating taste issues. Most butyrate research uses mineral salts that are hard to formulate into a drinkable product. L-lysine butyrate solves that problem and makes daily use actually practical.
Metabolex Chromium | 300mcg per serving
What it is
Chromium is an essential trace mineral that plays a central role in how your body handles insulin and blood sugar. It's been studied for decades as a supplement for blood sugar support, carb cravings, and insulin sensitivity.
We deliver chromium through Metabolex, a patented form that binds chromium to ursolic acid (chromium polyursolate). This bond makes the chromium more bioavailable than standard chromium picolinate and delivers 10mg of ursolic acid as part of the same molecule.
How it works
Chromium enhances insulin receptor sensitivity, which means your cells respond more efficiently when insulin shows up with glucose. That matters for cravings because one of the biggest drivers of snacking is a blood sugar crash after a meal. When insulin sensitivity improves, blood sugar stays steadier, and the "feed me now" signal quiets down.
What the research shows
1. Chromium picolinate attenuated weight gain and improved insulin sensitivity in type 2 diabetes. A 2006 randomized controlled trial in Diabetes Care followed adults with type 2 diabetes on sulfonylurea therapy (a medication known to promote weight gain). The chromium picolinate group gained significantly less weight and improved insulin sensitivity compared to placebo. (Martin et al., 2006, Diabetes Care)
2. Meta-analysis of 25 RCTs confirmed chromium improves glycemic control. A 2014 systematic review and meta-analysis in the Journal of Clinical Pharmacy and Therapeutics pooled data from 25 randomized controlled trials and found chromium supplementation reduced HbA1c (a 3-month blood sugar average) by a mean of 0.55%. That's a clinically meaningful effect in the same ballpark as some first-line oral diabetes medications. (Suksomboon et al., 2014, J Clin Pharm Ther)
3. Chromium picolinate reduced carbohydrate cravings in an 8-week RCT. A double-blind, placebo-controlled, multicenter trial in 113 adults tested 600mcg of chromium picolinate against placebo. The chromium group showed significant reductions in carbohydrate cravings, appetite, and increased eating compared to placebo. In the subgroup with high baseline carb cravings, 65% responded to chromium versus 33% on placebo. (Docherty et al., 2005, J Psychiatr Pract)
Chromium's role in insulin signaling and blood sugar support is one of the most extensively documented mineral functions in nutrition research, with human trials going back to the 1980s. The three studies above are the cleanest receipts on the blood sugar and craving side of the equation.
Why 300mcg
300mcg sits in the sweet spot of the published research, which typically tests doses between 200mcg and 1000mcg. It's above the adequate intake level for adults (25-35mcg) and within the range used in clinical studies on insulin sensitivity and blood sugar support.
Konjac Root (Glucomannan) | 500mg per serving
What it is
Konjac glucomannan is a soluble fiber extracted from the root of the konjac plant (Amorphophallus konjac), a staple in Japanese cooking for centuries. It's what shirataki noodles are made from. It has one unusual property: it absorbs up to 50 times its weight in water.
How it works
When you drink konjac with water, it expands into a gel in your stomach. That gel creates physical fullness, slows how quickly your stomach empties, and moderates the rate at which carbohydrates hit your bloodstream. It's also fermented by gut bacteria, which triggers release of GLP-1 and PYY through the same pathway butyrate uses.
What the research shows
1. Glucomannan stimulates GLP-1 and PYY release and delays gastric emptying. A 2024 paper in the Journal of Agricultural and Food Chemistry demonstrated that konjac glucomannan supplementation enhanced the release of the satiety hormones GLP-1 and PYY while slowing gastric emptying. That's the same two-hormone axis that prescription GLP-1 drugs work through. (Chen et al., 2024, J Agric Food Chem)
2. Glucomannan significantly enhanced satiety and reduced hunger in a human RCT. A randomized crossover trial in healthy individuals tested gelled konjac glucomannan against control preloads. The glucomannan group showed significant reductions in hunger, increases in fullness, and decreases in prospective food consumption, with the effect scaling with fiber viscosity. (Tester & Al-Ghazzewi, 2017, Br J Nutr)
3. A systematic review found glucomannan reduces body weight, BMI, and waist circumference. A recent systematic review covering 10 randomized controlled trials reported that glucomannan supplementation was consistently associated with reductions in body weight, BMI, and waist circumference in overweight and obese adults, with the mechanism tied to delayed gastric emptying, satiety hormone release, and gut microbiota regulation. (Zalewski et al., 2015, Nutrition)
Glucomannan is one of the few fibers with an FDA-recognized role in appetite support, and it's been studied in weight, cholesterol, blood sugar, and satiety research for over 30 years. The three studies above are the tightest receipts on its role in GLP-1, PYY, and satiety.
Why 500mg
Clinical studies on konjac use doses ranging from 500mg to 3g, typically taken before meals with water. 500mg is at the practical end for a beverage format and pairs with the 8-16oz of water you drink Ozzi with. Higher doses can cause digestive discomfort for people who aren't used to fiber, so we built Ozzi to be gentle enough for daily use.
African Mango Extract (Irvingia gabonensis) | 150mg per serving
What it is
African mango is the seed of a fruit native to West Africa, used in Cameroonian cooking and traditional medicine for generations. The seed extract, Irvingia gabonensis, became a research target in the 2000s when clinical trials from Cameroon-based researchers reported effects on body weight, waist circumference, and lipid profiles.
How it works
The most interesting mechanism for appetite is its relationship with leptin. Leptin is the hormone your fat cells release to tell your brain you've had enough food. In people carrying extra weight, leptin signaling often gets blunted, which is part of why the brain keeps asking for food even when the body has stored energy. African mango appears to support leptin sensitivity, meaning your brain can hear the satiety signal better.
What the research shows
1. African mango improved weight, waist, leptin, and adiponectin in a 10-week human RCT. A randomized, double-blind, placebo-controlled trial in Lipids in Health and Disease tested IGOB131 (150mg twice daily before meals) in 102 overweight adults. The treatment group showed significant reductions in body weight, waist circumference, and body fat, along with a significant drop in leptin and a rise in adiponectin, the two main hormones involved in appetite and fat storage. (Ngondi et al., 2009, Lipids Health Dis)
2. An earlier human RCT confirmed weight and metabolic benefits. A 2008 randomized, double-blind, placebo-controlled trial in Lipids in Health and Disease tested Irvingia gabonensis seed extract in overweight adults over 1 month. The treatment group showed significant decreases in body weight, body fat, and waist circumference, along with improvements in total cholesterol and LDL. (Oben et al., 2008, Lipids Health Dis)
3. Systematic review confirmed the effect across multiple RCTs. A 2013 systematic review in the Journal of Dietary Supplements reviewed the randomized controlled trials on Irvingia gabonensis in overweight and obese adults. The review concluded that the evidence from clinical trials supports a role for African mango in reducing body weight, waist circumference, and metabolic risk markers. (Onakpoya et al., 2013, J Diet Suppl)
African mango has been studied specifically for its effects on leptin, adiponectin, and the PPAR-gamma pathway, which ties it into the same satiety and fat metabolism axis that GLP-1 drugs target.
Why 150mg
Most of the published Irvingia gabonensis clinical research uses doses in the 150mg-300mg range, taken once or twice daily. 150mg per serving sits right at the starting dose used in the clinical trials and works well as one piece of a broader formula.
Metabolex Ursolic Acid | 10mg per serving
What it is
Ursolic acid is a plant compound found naturally in the waxy skin of apples, basil, and rosemary. It's one of the more interesting recent additions to the metabolic support category because it works through a completely different pathway than the other ingredients in Ozzi.
We deliver ursolic acid through Metabolex, a patented form where ursolic acid is bound to chromium (chromium polyursolate). That means every serving of Ozzi delivers both 300mcg of chromium and 10mg of ursolic acid from the same molecule.
How it works
Ursolic acid activates AMPK, the cellular energy sensor that tells your body to burn fat for fuel instead of storing it. In preclinical research, it's also been shown to support skeletal muscle and brown fat, which is the metabolically active fat that burns calories to produce heat.
What the research shows
1. Ursolic acid drove remission of metabolic syndrome in a human RCT. A 2017 randomized, double-blind, placebo-controlled clinical trial in the Journal of Medicinal Food tested 150mg of ursolic acid daily for 12 weeks in adults with metabolic syndrome. 50% of the ursolic acid group experienced remission of metabolic syndrome, with significant reductions in body weight, BMI, waist circumference, and fasting glucose, alongside increased insulin sensitivity. (Ramírez-Rodríguez et al., 2017, J Med Food)
2. Ursolic acid increased brown fat and muscle while reducing obesity. A 2012 study in PLOS One showed that ursolic acid supplementation increased skeletal muscle, increased brown adipose tissue (the "good" fat that burns calories), and decreased diet-induced obesity, glucose intolerance, and fatty liver disease. This is the foundational paper on ursolic acid's effect on body composition. (Kunkel et al., 2012, PLOS One)
3. Ursolic acid boosts energy expenditure through AMPK activation. A 2015 study in the Journal of Nutritional Biochemistry demonstrated that ursolic acid increases energy expenditure by enhancing free fatty acid uptake and beta-oxidation through the UCP3/AMPK pathway in skeletal muscle. This explains the mechanism behind the body composition effects seen in the human and animal studies. (Kim et al., 2015, J Nutr Biochem)
The takeaway across these studies is consistent. Ursolic acid helps reshape body composition from two directions at once: more calorie-burning tissue (muscle and brown fat) and better insulin sensitivity. That's a rare combo, and it's why we included it.
Why 10mg
Ursolic acid is potent at low doses. 10mg is where the research starts to show meaningful mechanistic effects, and it comes naturally bundled with the 300mcg of chromium in Metabolex. We didn't need to add ursolic acid separately because Metabolex delivers both actives in one bioavailable form.
What's NOT in Ozzi
We built Ozzi to be usable every day, which means keeping it clean.
Zero caffeine
Zero added sugar
Zero artificial sweeteners (sucralose, aspartame, acesulfame K)
Zero synthetic stimulants
Zero berberine
No artificial colors or dyes
No preservatives
Non-GMO
Gluten free
Vegan
Sourcing & Manufacturing
Ozzi is made in the USA in a cGMP-certified facility. Every active ingredient is third-party tested for purity, potency, and contaminants (heavy metals, microbials, pesticides) before it goes into production.
We use branded, patented ingredient forms (allSWEET, BIOMEnd, Metabolex) because they come with their own documentation on sourcing, stability, and quality. That means we know exactly what's in every stick pack, down to the milligram.
All ingredients are tested and qualified upon arrival.
All lots are safety tested for bacteria and heavy metals to ensure safety.
References
Teysseire F, et al. The role of D-allulose and erythritol on the activity of the gut sweet taste receptor and gastrointestinal satiation hormone release in humans: a randomized, controlled trial. J Nutr. 2022;152(5):1228-1238. pubmed.ncbi.nlm.nih.gov/35135006
Braunstein CR, et al. Allulose for the attenuation of postprandial blood glucose levels in healthy humans: A systematic review and meta-analysis. PLOS One. 2023. pubmed.ncbi.nlm.nih.gov/37023000
Kishida K, et al. Impact of allulose on blood glucose in type 2 diabetes: A meta-analysis of clinical trials. Clin Nutr ESPEN. 2024. pubmed.ncbi.nlm.nih.gov/39583955
Yadav H, et al. Beneficial metabolic effects of a probiotic via butyrate-induced GLP-1 hormone secretion. J Biol Chem. 2013;288(35):25088-25097. pubmed.ncbi.nlm.nih.gov/23836895
Chen HL, et al. Konjac glucomannan supplementation on gastrointestinal hormone response and satiety. J Agric Food Chem. 2024. pubmed.ncbi.nlm.nih.gov/39441122
Martin J, et al. Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care. 2006;29(8):1826-1832. pubmed.ncbi.nlm.nih.gov/16873787
Ngondi JL, et al. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigation. Lipids Health Dis. 2009;8:7. pmc.ncbi.nlm.nih.gov/articles/PMC2651880
Onakpoya I, et al. The efficacy of Irvingia gabonensis supplementation in the management of overweight and obesity: a systematic review of randomized controlled trials. J Diet Suppl. 2013. pubmed.ncbi.nlm.nih.gov/23419021
Kim J, et al. Ursolic acid increases energy expenditure through enhancing free fatty acid uptake and β-oxidation via an UCP3/AMPK- dependent pathway in skeletal muscle. J Nutr Biochem. 2015. pubmed.ncbi.nlm.nih.gov/25944715
Kunkel SD, et al. Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease. PLOS One. 2012;7(6):e39332. pubmed.ncbi.nlm.nih.gov/22745735
Disclaimer: This page is for informational purposes only and does not constitute medical advice. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any new supplement, especially if you have diabetes, take medications, are pregnant or breastfeeding, or have other health conditions. Individual results may vary.