Appetite After Stopping GLP-1 Medications
Support Your Own Satiety Signals Through The Transition
When the medication stops, your own appetite signaling comes back loud. That is documented, not a personal failure. Ozzi is a daily drink stick with six actives at published doses that supports your body's natural GLP-1 production. It is not a replacement for your prescription, and nothing over the counter is.
From $55.00 a bag. Free US shipping on orders over $75.
Take medications, or pregnant or breastfeeding? Ask your doctor first. Every dose is on the label, and it's third-party certified, so it's a short conversation.
Digestive Health: Supports gut health & gut-brain connection.*
Blood Sugar: Promotes a healthy blood-sugar response.*
Metabolic Health: Supports fat metabolism & regulates appetite.*
Natural GLP-1: Stimulates L-Cells for GLP-1 and PYY Secretion.*
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Take it for 14 straight days. If your cravings and food noise aren't quieter, we'll refund your first bag.
Certified to NSF/ANSI 173 by Eurofins · Recommended by 750+ clinicians
How To Use
Since Ozzi is caffeine and sugar free, you can take it at any time your cravings start to hit.
Mix Ozzi with 16-20oz of chilled water.
If you'd like some bubbles, you can mix with ~4oz of still water, then pour in sparkling water on top slowly to avoid foam spilling over.
Pro Tip: Use daily for best results. Start with 1/2 if you have a sensitive gut.
What To Expect
You're fine all day. Then the couch, the quiet, and the evening pull toward the snack drawer. That's the moment Ozzi was built for. Here's how it plays out.
DAY 1: Ozzi works fast. Allulose satisfies your sweet tooth without spiking your blood sugar, and the fiber starts to fill you up, so the evening cookie pull gets weaker.†
DAY 7: Butyrate is feeding your gut lining and the cells behind your fullness hormones.‡ You might notice a steadier appetite and fewer "I'm not even hungry" snack runs.
DAY 30: Your gut and brain are communicating better. Ozzi supports your body's natural GLP-1 and PYY, the signals that tell you you're full, plus a healthy blood-sugar response. Less food goes further.‡
MONTH 2+: Reaching for Ozzi instead of the snack drawer is just what you do now. The habit's stuck, and the benefits keep building.
† Based on ingredient mechanisms: allulose tastes sweet but isn't metabolized like sugar, so it doesn't raise blood glucose; glucomannan, a soluble fiber, forms a gel that promotes fullness.
‡ Butyrate is the primary fuel for gut-lining cells and, with other short-chain fatty acids, stimulates GLP-1 and PYY release from intestinal L-cells in laboratory and animal research. Allulose has been shown to support a healthy post-meal blood-sugar response in human studies at comparable doses. Individual results vary.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Ingredients & Allergies
Ingredients
Ozzi contains 6 clinically studied active ingredients:
Allulose, Konjac Glucomannan, L-Lysine Butyrate (as BIOMEnd), African Mango Extract (Irvingia gabonensis seed), and Chromium Polyursolate (as Metabolex, chromium bound to ursolic acid). Each stick also delivers 860% daily value of Chromium.
Other ingredients: Citric Acid, Silica, Natural Flavor, L-Tartaric Acid, Reb M (OnoSweet), Pink Himalayan Sea Salt, and Trisodium Citrate.
5 calories per stick. 0g sugar. No caffeine. No monk fruit. No stevia. No synthetic dyes or sweeteners.
Allergies
Ozzi is free from dairy, nuts, soy, monk fruit, and stevia. Contains no caffeine and no artificial colors.
Despite the name, African mango isn't actually mango. Ozzi uses African mango (Irvingia gabonensis), a seed from a completely different plant family than the common mango (Mangifera indica) you find at the grocery store.
Here's why that matters. The compound behind most mango skin reactions is urushiol, the same irritant found in poison ivy and poison oak. It turns up in common mango because mango sits in the same plant family (Anacardiaceae) as poison ivy, cashews, and pistachios. African mango isn't in that family, so it doesn't carry urushiol.
If you have specific dietary concerns, please review the full supplement facts label or contact us before use.
Natural GLP-1
GLP-1 is a natural hormone your body produces. It binds to receptors in your brain for 3 minutes before it is cleared, but it turns the receptor on for hours.
GLP-1 Agonists, commonly referred to just as "GLP-1", are a pharmaceutical mimic of your natural hormone. They stay active in the body for about a week.
Ozzi is formulated to help support your body's natural GLP-1 secretion.
Here's what customers who've tried GLP-1 medications are saying about Ozzi:
"I cannot say enough about this product. I was on a GLP-1 for 2 years and benefited most from the food noise reduction. I chose to get off of it due to its high cost. I have tried absolutely everything on the market and nothing, absolutely nothing has had the same effect until I came across Ozzi. I am a customer for life! This product is genuinely revolutionary for those who have struggled with ongoing cravings and food noise. I'm locked in. Thank you, thank you!" - Noralyn
"I've been using Ozzi for just a few days now but it definitely curbs my hunger. It's so much more pleasant than the feeling I got from the GLP-1 meds. No nausea at all. And it tastes great too!" - Dan
Not everyone will experience the same results. That's why we offer the 14-Day Ozzi Challenge: take it for 14 straight days, and if your cravings and food noise aren't quieter, we'll refund your first bag.
Shipping & Returns
Orders are shipped within 1-2 business days. Our team works hard to get most orders out the same day, as long as they're placed prior to 1pm ET.
Orders ship from Fort Worth, TX and arrive to most customers in 2-5 business days.
Shipping is free on orders of $75+ and subscriptions.
To pause, edit, or cancel a subscription, please click here.
As Ozzi is a food product, we are unable to accept returns.
The hunger is real, and it is not a willpower problem
Your last dose was a few weeks ago and food is loud again. You are thinking about dinner at eleven in the morning. That is not you slipping.
The medication was doing appetite-signaling work at a magnitude your own body does not reach on its own. It slowed how fast your stomach emptied and it steadied the signal that tells your brain you have had enough. When the dose stops, that work stops with it, and your own signaling comes back online. It comes back loud, because it has been running against a much stronger signal the whole time.
This is documented physiology, not a character flaw. If you want the hormone explained from the beginning, start with what GLP-1 actually is.
What the research actually shows about stopping
Numbers, reported as numbers.
A 2026 systematic review and nonlinear meta-regression in eClinicalMedicine pooled 48 studies and modelled six randomised trials covering 3,236 people. At one year after stopping, an average of 60% of the weight lost during treatment had returned, and the model projected the regain plateauing at about 75% of what was lost. 1 The second half of that finding matters as much as the first, so here it is out loud: the regain decelerates and plateaus below where people started, which means part of the benefit persists.
The STEP 1 trial extension followed people for a year after withdrawal and found weight and cardiometabolic markers moving back toward baseline. 2
A 2026 review in Diabetes, Obesity and Metabolism looks specifically at the mechanisms of early regain after discontinuation, and at how clinicians think about de-escalating treatment. 3
None of that is a reason to stay on or to come off anything. It is a reason to expect the appetite change instead of being blindsided by it.
Why appetite stays loud even after the medication clears
There is a second mechanism, and it is the one that explains why the hunger outlasts the drug in your system. Losing weight changes your appetite hormones by itself. Sumithran and colleagues, writing in the New England Journal of Medicine in 2011, followed people for a full year after a weight-loss diet and found the hormonal drivers of appetite, ghrelin among them, still shifted toward hunger at twelve months. 4
So two things are happening at once, and only one of them is about the medication. Your body is defending the weight it lost. That is exactly why "just eat less" advice lands so badly right now.
What Ozzi does, and the part it does not do
Start with the limit, because it is the honest place to start. Nothing you can buy without a prescription works the way GLP-1 medications work, Ozzi included.
What Ozzi does is support your body's own GLP-1 production and satiety signaling, with six actives at published doses: 8g allulose, 500mg konjac glucomannan, 500mg L-lysine butyrate as BIOMEnd, 150mg African mango, and chromium at roughly 300mcg with about 10mg ursolic acid as Metabolex.
The evidence behind those, labelled by strength:
- Human. Allulose reaching the sweet taste receptors in your gut and moving satiation hormone release, in a randomised controlled trial. 5
- Preclinical. Butyrate stimulating GLP-1 secretion in cell and mouse work. Mouse. Human confirmation is not there yet, which is exactly why the language here stays at "supports natural GLP-1 production" and never goes past it. 6
- Physical. Konjac glucomannan is a viscous fiber, and the fullness from it is immediate and mechanical.
Every dose is printed on the label, so you can hand it to your prescriber and get a two-minute answer. If you never took a medication and arrived here anyway, natural GLP-1 support, explained is the page written for you.
Where the taper decision belongs
Whether to come off, when, and how fast is a conversation with the person who prescribed it. Nothing on this page is a reason to change a dose, and we are not going to pretend otherwise in order to sell you a drink.
The transition protocol itself, meaning protein, resistance training, the habits that hold, and how to raise all of it with your prescriber, is covered in our guide to coming off GLP-1 medications. There is more in Health Guides and in all our guides.
The 14-day test
14-Day Ozzi Challenge: Take it for 14 straight days. If your cravings and food noise aren't quieter, we'll refund your first bag.
The terms, plainly: refunds are valid within 28 days of delivery, with daily use confirmed. There are no returns, so keep the bag either way. Ozzi is certified to NSF/ANSI 173 by Eurofins under certificate 20260428-0002, and it is recommended by 750+ clinicians, including clinicians at Gameday Men's Health, clinics that prescribe GLP-1 medications and recommend Ozzi to patients who do not qualify for them.
References
- Budini B, et al. Trajectory of weight regain after cessation of GLP-1 receptor agonists: a systematic review and nonlinear meta-regression. eClinicalMedicine. 2026. PubMed 41938838
- Wilding JPH, et al. Diabetes, Obesity and Metabolism. 2022. PubMed 35441470
- Damhof MA, et al. Early Weight Regain After GLP-1 Receptor Agonist Discontinuation: Mechanisms and Implications for Treatment De-Escalation Strategies. Diabetes, Obesity and Metabolism. 2026. PubMed 42396734
- Sumithran P, et al. Long-term persistence of hormonal adaptations to weight loss. New England Journal of Medicine. 2011. PubMed 22029981
- Teysseire F, et al. The Role of D-allulose and Erythritol on the Activity of the Gut Sweet Taste Receptor and Gastrointestinal Satiation Hormone Release in Humans: A Randomized, Controlled Trial. Journal of Nutrition. 2022. PubMed 35135006
- Yadav H, et al. Beneficial metabolic effects of a probiotic via butyrate-induced GLP-1 hormone secretion. Journal of Biological Chemistry. 2013. PubMed 23836895
What Comes Back, When
Averages, not promises. Your taper schedule and your timeline belong to you and your prescriber.
Week 1 to 2
Appetite comes back first
Physical hunger returns before anything else does. The medication was slowing how fast your stomach emptied and steadying your appetite signaling, and when the dose stops, that work stops with it.
What helps here Consistency beats intensity. Ozzi daily, in the window your cravings are worst, usually evening. The fiber fullness is immediate.*
Week 2 to 6
Food noise ramps
The constant thinking about food is usually the part people miss most. It comes back on its own schedule, separate from physical hunger, and it catches people off guard because they thought hunger was the whole problem.
What helps here This is the window the 14-day guarantee is built around. Daily use, no skipped days, and judge it on whether food noise gets quieter.*
Week 6 to 12
Portions feel smaller than they are
Weight loss itself shifts appetite hormones, and research shows those shifts persist well past the diet. So this is not only about the medication leaving your system. Your body is defending the weight it lost.
What helps here Protein at every meal and resistance training do the heaviest lifting here. Ozzi supports the satiety side of it.*
Month 3 and on
The new steady state
Research on people who stop these medications shows regain slows over time rather than running away. On average, people in the research held on to part of what they lost. The habits you build now are what decide how much.
What helps here The daily stick is the easiest habit on the list to keep. Everything else on that list is harder.*
Two Customers Who Came Off
Individual experiences, printed in full and in their own words. Read them as experiences, not as evidence.
"I cannot say enough about this product. I was on a GLP-1 for 2 years and benefited most from the food noise reduction. I chose to get off of it due to its high cost. I have tried absolutely everything on the market and nothing, absolutely nothing has had the same effect until I came across Ozzi. I am a customer for life! This product is genuinely revolutionary for those who have struggled with ongoing cravings and food noise. I'm locked in. Thank you, thank you!"
Noralyn
Two years on a GLP-1 medication. Verified Ozzi customer.
Editor's note: One customer's experience. It is not evidence that Ozzi matches a prescription, and Noralyn is not saying it did.
"I've been using Ozzi for just a few days now but it definitely curbs my hunger. It's so much more pleasant than the feeling I got from the GLP-1 meds. No nausea at all. And it tastes great too!"
Dan
Switched from a GLP-1 medication. Verified Ozzi customer.
Editor's note: Tolerability, not equivalence. A supplement having no nausea is not a claim about results.
Recommended by 750+ clinicians
What a Doctor Says About Ozzi
"Drink packets curb cravings while promoting healthy blood sugar"
"When late-night cravings hit, I recommend this drink powder as a possible snack replacement. One ingredient I want to highlight is chromium polyursolate. Research on a related form, chromium picolinate, suggests that it may reduce food intake, lower hunger ratings, and decrease fat cravings in overweight women. Chromium can support insulin function and glucose metabolism, which may help keep blood sugar steady enough to avoid triggering cravings. I find this pairs nicely with the African Mango seed extract in this blend, which research suggests may be connected to improvements in body weight, waist size, and fasting blood sugar. Overall, I believe this supplement can be a helpful option for patients looking to manage cravings and support metabolic health."†
Review provided through FrontRow Health's verified clinician program. †These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. If you take medications, especially for blood sugar, talk to your doctor before starting any supplement. Ozzi is third-party certified to NSF/ANSI 173: see testing and certification.
From people who've tried GLP-1 medications
"I cannot say enough about this product. I was on a GLP-1 for 2 years and benefited most from the food noise reduction. I chose to get off of it due to its high cost. I have tried absolutely everything on the market and nothing, absolutely nothing has had the same effect until I came across Ozzi. I am a customer for life!"
Noralyn · verified Ozzi customer
"I've been using Ozzi for just a few days now but it definitely curbs my hunger. It's so much more pleasant than the feeling I got from the GLP-1 meds. No nausea at all. And it tastes great too!"
Dan · verified Ozzi customer
Mother Nature's Best Crave Crushing Ingredients
6 Clinically Studied Ingredients, At The Doses Found Effective.
Enjoy Ozzi Day Or Night
The Easiest Way To
Crush Cravings
Step 1: Pour
Just rip the easy-tear tab on your Ozzi, precisely dosed and easy to grab-and-go.
Step 2: Mix
Mix it with a spoon or frother for a few seconds to properly mix the flavor.
Step 3: Sip
Enjoy as quickly or slowly as you'd like.
Coming Off, Answered
The questions people actually search once the medication stops. More on the FAQ page.
Should I stop my GLP-1 medication?
That is your prescriber's call, not ours, and not the internet's. Whether to stop, when, and how fast depends on why you started and what your labs look like, and nothing you read here is a reason to change a dose.
What we can help with is the part that comes after: the returning appetite and food noise. Ozzi is a daily drink that supports your body's own GLP-1 production and satiety signaling. It is not a replacement for a prescription, and nothing sold over the counter is.
Why am I so hungry after stopping GLP-1 medications?
Because the medication was doing the appetite-signaling work, and when it stops, that work stops with it. Your own signaling comes back online, and it feels loud by comparison.
There is a second reason too: losing weight itself shifts your appetite hormones toward hunger, and research has found those shifts still present a full year later. Two things at once, and neither one is a willpower problem.
How long does rebound hunger last after coming off?
Physical hunger usually returns within days to a couple of weeks. Food noise tends to ramp on its own schedule after that, which surprises people who thought hunger was the whole problem.
It settles rather than climbing forever, but there is no fixed date, and anyone giving you one is guessing.
Will I gain the weight back after stopping GLP-1 medications?
The honest answer is that regain is common and documented. A 2026 systematic review pooling 48 studies found that at one year after stopping, an average of 60% of the weight lost during treatment had returned, with the model projecting a plateau around 75%.
The same analysis found the regain decelerates and settles below where people started, so part of the benefit tends to persist. We cannot promise you a number, and neither can anyone else.
Is there anything that works like the medication once you stop?
No. Nothing you can buy without a prescription works the way GLP-1 medications work, Ozzi included, and any brand telling you otherwise is selling too hard.
What a well-dosed supplement can do is support the signaling your own body runs. Ozzi does that with 8g of allulose, 500mg of konjac glucomannan, and 500mg of L-lysine butyrate, at the doses printed on the label.
Can I take Ozzi while I am still on my GLP-1 medication?
Ask your prescriber first, and we mean that literally. Chromium can affect blood sugar, and viscous fibers like glucomannan can change how some oral medications absorb.
Every dose in Ozzi is on the label, so bring it to your appointment and it is a two-minute conversation. Plenty of customers use it alongside a prescription, plenty start after, and both should go past the person managing your care.
How do I stop food noise coming back?
You probably will not stop it entirely, and framing it that way sets you up to feel like you failed. The realistic goal is quieter, not silent. Protein at every meal, resistance training, and sleep do real work here.
Ozzi's job is the satiety side: it supports your body's own GLP-1 production so the signal telling you that you have had enough actually registers.
What should I do in the first month after my last dose?
Expect the appetite change instead of being surprised by it, keep protein high, start or keep resistance training so you hold on to muscle, and pick one daily habit simple enough that you will actually do it on a bad week.
Our guide to coming off GLP-1 medications covers the protocol in detail, and the taper schedule itself stays between you and your prescriber.
How fast does Ozzi work?
The fullness from the fiber is immediate. The satiety-signaling side builds with daily use, so for most people the change in cravings and food noise becomes noticeable inside the first two weeks.
That is why the guarantee runs exactly 14 straight days. Skipping days works against you.
What if it does not work for me?
14-Day Ozzi Challenge: Take it for 14 straight days. If your cravings and food noise aren't quieter, we'll refund your first bag.
There is nothing to send back, because we do not do returns. Keep the bag either way. Email help@heyozzi.com with your order number and confirm you used it daily for two weeks. Refunds are valid within 28 days of delivery.
Can you manage weight without GLP-1 medications?
Plenty of people do, and the honest framing matters here. When the medication stops, appetite and food noise come back. That is the variable that actually changed. Nobody handed you new willpower; a hormone signal was turned up and then turned off again.
Ozzi is daily support for the craving side of that, with six actives at printed doses. We are not going to tell you it keeps weight off, because that is not a claim we can make. What it supports is quieter cravings and food noise.
Is there a natural GLP-1 supplement that works after medication?
Be careful with the word works. Allulose and butyrate are both studied for their effects on GLP-1 signaling, and butyrate's GLP-1 evidence is in mouse and cell studies so far. That is support for your body's own production, not a substitute for a prescription medication, and the effects are not comparable in size. Anyone telling you otherwise is selling too hard.
What that support is good for is the appetite and food noise side after your last dose. 14-Day Ozzi Challenge: Take it for 14 straight days. If your cravings and food noise aren't quieter, we'll refund your first bag.
Ozzi is not a replacement for your prescription, and nothing sold over the counter is. What it does is support your body's own GLP-1 production and satiety signaling, at doses printed on the label, for the stretch where your appetite is loud again.
14-Day Ozzi Challenge: Take it for 14 straight days. If your cravings and food noise aren't quieter, we'll refund your first bag.
Try Ozzi for 14 daysRefunds are valid within 28 days of delivery, with daily use confirmed. There is nothing to send back, because we do not do returns. Keep the bag either way.