4.213,000+ customers

Natural GLP-1 Support Drink

Support Your Body's Own Fullness Hormone

A caffeine-free drink for cravings and food noise, with 8 g allulose and five other actives selected for fullness, glucose and gut-signaling research.

Snack Less94% say they snack less
Fuller, Faster83% say they feel full faster
Less Food Noise83% say their food noise went down
Embrace the FunkCustomers say the smell goes away after mixing

Ozzi customer survey, 66 customers · June to September 2026 · Self-reported

Roll a 6 and your entire order is free

Every one-time order comes with one roll of the die after checkout, unless it uses a 15% off code. Roll a 6 and we refund everything you paid. Your order still ships.

No purchase necessary. Open to legal residents of the 50 U.S. states and DC, except FL and NY, 18 or older. Ends 12/31/26. Odds of winning are 1 in 6 per roll. Void where prohibited. Florida and New York residents: see the separate promotions. Official rules and free entry: roll.heyozzi.com/rules. Sponsor: Ozzi, Inc.

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14-Day Ozzi Challenge

Take it for 14 straight days. If your cravings and food noise aren't quieter, we'll refund your first bag.

How To Use

Since Ozzi is caffeine and sugar free, you can take it at any time your cravings start to hit.

Mix Ozzi with 16-20oz of chilled water.

If you'd like some bubbles, you can mix with ~4oz of still water, then pour in sparkling water on top slowly to avoid foam spilling over.

Pro Tip: Use daily for best results. Start with 1/2 if you have a sensitive gut.

What To Expect

You're fine all day. Then the couch, the quiet, and the evening pull toward the snack drawer. That's the moment Ozzi was built for. Here's how it plays out.

DAY 1: Ozzi works fast. Allulose satisfies your sweet tooth without spiking your blood sugar, and the fiber starts to fill you up, so the evening cookie pull gets weaker.†

DAY 7: Butyrate is feeding your gut lining and the cells behind your fullness hormones.‡ You might notice a steadier appetite and fewer "I'm not even hungry" snack runs.

DAY 30: Your gut and brain are communicating better. Ozzi supports your body's natural GLP-1 and PYY, the signals that tell you you're full, plus a healthy blood-sugar response. Less food goes further.‡

MONTH 2+: Reaching for Ozzi instead of the snack drawer is just what you do now. The habit's stuck, and the benefits keep building.

† Based on ingredient mechanisms: allulose tastes sweet but isn't metabolized like sugar, so it doesn't raise blood glucose; glucomannan, a soluble fiber, forms a gel that promotes fullness.

‡ Butyrate is the primary fuel for gut-lining cells and, with other short-chain fatty acids, stimulates GLP-1 and PYY release from intestinal L-cells in laboratory and animal research. Allulose has been shown to support a healthy post-meal blood-sugar response in human studies at comparable doses. Individual results vary.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Ingredients & Allergies

Ingredients

Ozzi contains 6 clinically studied active ingredients:

Allulose, konjac glucomannan, L-lysine butyrate (BIOMEnd), African mango seed extract, ursolic acid and chromium. The last two are supplied together through Metabolex chromium polyursolate. Each stick also delivers 860% daily value of Chromium.

Other ingredients: Citric Acid, Silica, Natural Flavor, L-Tartaric Acid, Reb M (OnoSweet), Pink Himalayan Sea Salt, and Trisodium Citrate.

5 calories per stick. 0g sugar. No caffeine. No monk fruit. No synthetic dyes or sweeteners.

Allergies

Ozzi is free from dairy, nuts, soy, and monk fruit. Contains no caffeine and no artificial colors.

Despite the name, African mango isn't actually mango. Ozzi uses African mango (Irvingia gabonensis), a seed from a completely different plant family than the common mango (Mangifera indica) you find at the grocery store.

Here's why that matters. The compound behind most mango skin reactions is urushiol, the same irritant found in poison ivy and poison oak. It turns up in common mango because mango sits in the same plant family (Anacardiaceae) as poison ivy, cashews, and pistachios. African mango isn't in that family, so it doesn't carry urushiol.

If you have specific dietary concerns, please review the full supplement facts label or contact us before use.

Natural GLP-1

GLP-1 is a hormone released by your gut after eating. Active GLP-1 is rapidly broken down, with a circulating half-life of roughly 1–2 minutes. That is not the same as receptor binding time.

GLP-1 Agonists, commonly referred to just as "GLP-1", are a pharmaceutical mimic of your natural hormone. They stay active in the body for about a week.

Ozzi is formulated to help support your body's natural GLP-1 secretion.

Here's what customers who've tried GLP-1 medications are saying about Ozzi:

"I cannot say enough about this product. I was on a GLP-1 for 2 years and benefited most from the food noise reduction. I chose to get off of it due to its high cost. I have tried absolutely everything on the market and nothing, absolutely nothing has had the same effect until I came across Ozzi. I am a customer for life! This product is genuinely revolutionary for those who have struggled with ongoing cravings and food noise. I'm locked in. Thank you, thank you!" - Noralyn

"I've been using Ozzi for just a few days now but it definitely curbs my hunger. It's so much more pleasant than the feeling I got from the GLP-1 meds. No nausea at all. And it tastes great too!" - Dan

Not everyone will experience the same results. That's why we offer the 14-Day Ozzi Challenge: take it for 14 straight days, and if your cravings and food noise aren't quieter, we'll refund your first bag.

Shipping & Returns

Orders are shipped within 1-2 business days. Our team works hard to get most orders out the same day, as long as they're placed prior to 1pm ET.

Orders ship from Fort Worth, TX and arrive to most customers in 2-5 business days.

Shipping is free on orders of $75+ and subscriptions.

To pause, edit, or cancel a subscription, please click here.

As Ozzi is a food product, we are unable to accept returns.

SUPPORTS NATURAL GLP-1*

SUPPORTS GUT HEALTH*

SUPPORTS INSULIN RESPONSE*

REDUCES APPETITE*

CRUSHES CRAVINGS*

NO DAIRY

NO SUGAR

NO CAFFEINE

NO GLUTEN

3RD PARTY TESTED

SUPPORTS NATURAL GLP-1*

SUPPORTS GUT HEALTH*

SUPPORTS INSULIN RESPONSE*

REDUCES APPETITE*

CRUSHES CRAVINGS*

NO DAIRY

NO SUGAR

NO CAFFEINE

NO GLUTEN

3RD PARTY TESTED

Our natural GLP-1 support approach

We designed Ozzi for cravings and food noise, especially in the evening. Our six drink actives bring together research on fullness, glucose responses and gut signaling. A natural-support supplement and a prescription GLP-1 receptor agonist have different evidence and effects.

Why 8 g allulose?

Our amount was informed by human glucose research around 7.5–10 g. Separate human experiments measured GLP-1 at 10 g and 25 g. We keep the serving rationale and those hormone findings distinct. Effects of D-allulose on glucose tolerance and insulin response to a standard oral sucrose load: results of a prospective, randomized, crossover study.; Differential Modulation of Postprandial Glycemic, Incretin, and Satiety Responses by Low-Digestible Carbohydrates in Humans: An Exploratory Investigation.; The Role of D-allulose and Erythritol on the Activity of the Gut Sweet Taste Receptor and Gastrointestinal Satiation Hormone Release in Humans: A Randomized, Controlled Trial..

Butyrate and konjac bring different evidence

Human sodium-butyrate trials include positive and nonsignificant GLP-1 findings. The BIOMEnd form has a small human absorption comparison, which did not measure craving relief. Konjac research includes fullness-related meal experiments and mixed supplement findings. Effect of Butyrate and Inulin Supplementation on Glycemic Status, Lipid Profile and Glucagon-Like Peptide 1 Level in Patients with Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Trial.; Expression of PGC-1α, PPAR-α and UCP1 genes, metabolic and anthropometric factors in response to sodium butyrate supplementation in patients with obesity: a triple-blind, randomized placebo-controlled clinical trial.; A Pharmacokinetic Comparison of Three Butyrate Products; In vitro gastric emptying characteristics of konjac glucomannan with different viscosity and its effects on appetite regulation..

Explore the full formula

Our drink contains six actives: allulose, konjac glucomannan, L-lysine butyrate (BIOMEnd), African mango, ursolic acid and chromium. One stick contains 8 g allulose. Ursolic acid and chromium are supplied together through Metabolex chromium polyursolate, and we explain them as separate ingredients. See the full amounts and current labels.

The ingredient research below the FAQ opens into individual studies. For the complete evidence record, visit our Research library. Our capsule guide explains the allulose-free format and three-capsule directions.

Recommended by 950+ clinicians

What a Doctor Says About Ozzi

Dr. Anand Balasubramanian, MD Verified clinician · Internal medicine · 19 years in practice

"Drink packets curb cravings while promoting healthy blood sugar"

"When late-night cravings hit, I recommend this drink powder as a possible snack replacement. One ingredient I want to highlight is chromium polyursolate. Research on a related form, chromium picolinate, suggests that it may reduce food intake, lower hunger ratings, and decrease fat cravings in overweight women. Chromium can support insulin function and glucose metabolism, which may help keep blood sugar steady enough to avoid triggering cravings. I find this pairs nicely with the African Mango seed extract in this blend, which research suggests may be connected to improvements in body weight, waist size, and fasting blood sugar. Overall, I believe this supplement can be a helpful option for patients looking to manage cravings and support metabolic health."†

Craving controlBlood sugarMetabolic health

Review provided through FrontRow Health's verified clinician program. †These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. If you take medications, especially for blood sugar, talk to your doctor before starting any supplement. Ozzi is third-party certified to NSF/ANSI 173: see testing and certification.

From people who've tried GLP-1 medications

"I cannot say enough about this product. I was on a GLP-1 for 2 years and benefited most from the food noise reduction. I chose to get off of it due to its high cost. I have tried absolutely everything on the market and nothing, absolutely nothing has had the same effect until I came across Ozzi. I am a customer for life!"

Noralyn · verified Ozzi customer

"I've been using Ozzi for just a few days now but it definitely curbs my hunger. It's so much more pleasant than the feeling I got from the GLP-1 meds. No nausea at all. And it tastes great too!"

Dan · verified Ozzi customer

What will you feel over time?

Ozzi isn't a stimulant or a suppressant. It supports the signals your body already uses, and it does more the longer you stick with it.

Woman holding a glass of Ozzi in her kitchen next to a grape Crave Crusher bag
  1. Day 1

    Cravings ease off

    Fast-acting ingredients reduce carb cravings, satiate your sweet tooth, and fill you up.*

  2. Week 1

    Your gut gets to work

    Butyrate supports your gut lining and fuels the cells that produce your fullness hormones.*

  3. Month 1

    Gut and brain in sync

    Your gut and brain are communicating better. Less food fills you up. Your energy is stable.*

  4. Month 3+

    The swap stuck

    You reach for Ozzi instead of the cookies, and you barely think about it. This is just how you eat now.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Join 13,000+ Ozzi Customers

Well, my biggest compliment is also a complaint. 🤪 Sometimes I want to eat out of boredom and I can.’t. My body and mouth will not crave anything. Also, true that constancy is key the second week was when it fully kicked in. Will be buying constantly. Will not run out. I refuse. 😊

Edyna R. Verified Customer

Great tasting product! I must confess I was a bit skeptical at first, having tried so many other products in the past. Ozzi definitely cuts down my evening cravings and the watermelon flavor is quite nice!

Vita D. Verified Customer

I love the cherry limeade and watermelon flavors. I drink one in the morning and one in the evening. Basically the times I'm usually craving something sweet. These help me feel satisfied.

Tianna J. Verified Customer

I've been really happy with the product. Not only does it help to curb hunger, but I no longer need my fiber supplements. I don't find the smell off-putting and the taste is great. It's been a winner for me!

Tricia C. Verified Customer

Ozzi does exactly what I wanted it to do - stop my evening munchies. I find it best if I drink it before the munchies have a chance to set in. And yeah - it definitely adds bulk to my "waste management." I already get plenty of fiber, so it took my body a couple days to recalibrate. Both favors are great, with a little zing. So it's a little treat in its own way.

Brian J. Verified Customer

Well, my biggest compliment is also a complaint. 🤪 Sometimes I want to eat out of boredom and I can.’t. My body and mouth will not crave anything. Also, true that constancy is key the second week was when it fully kicked in. Will be buying constantly. Will not run out. I refuse. 😊

Edyna R. Verified Customer

Great tasting product! I must confess I was a bit skeptical at first, having tried so many other products in the past. Ozzi definitely cuts down my evening cravings and the watermelon flavor is quite nice!

Vita D. Verified Customer

I love the cherry limeade and watermelon flavors. I drink one in the morning and one in the evening. Basically the times I'm usually craving something sweet. These help me feel satisfied.

Tianna J. Verified Customer

I've been really happy with the product. Not only does it help to curb hunger, but I no longer need my fiber supplements. I don't find the smell off-putting and the taste is great. It's been a winner for me!

Tricia C. Verified Customer

Ozzi does exactly what I wanted it to do - stop my evening munchies. I find it best if I drink it before the munchies have a chance to set in. And yeah - it definitely adds bulk to my "waste management." I already get plenty of fiber, so it took my body a couple days to recalibrate. Both favors are great, with a little zing. So it's a little treat in its own way.

Brian J. Verified Customer

Well, my biggest compliment is also a complaint. 🤪 Sometimes I want to eat out of boredom and I can.’t. My body and mouth will not crave anything. Also, true that constancy is key the second week was when it fully kicked in. Will be buying constantly. Will not run out. I refuse. 😊

Edyna R. Verified Customer

Great tasting product! I must confess I was a bit skeptical at first, having tried so many other products in the past. Ozzi definitely cuts down my evening cravings and the watermelon flavor is quite nice!

Vita D. Verified Customer

I love the cherry limeade and watermelon flavors. I drink one in the morning and one in the evening. Basically the times I'm usually craving something sweet. These help me feel satisfied.

Tianna J. Verified Customer

I've been really happy with the product. Not only does it help to curb hunger, but I no longer need my fiber supplements. I don't find the smell off-putting and the taste is great. It's been a winner for me!

Tricia C. Verified Customer

Ozzi does exactly what I wanted it to do - stop my evening munchies. I find it best if I drink it before the munchies have a chance to set in. And yeah - it definitely adds bulk to my "waste management." I already get plenty of fiber, so it took my body a couple days to recalibrate. Both favors are great, with a little zing. So it's a little treat in its own way.

Brian J. Verified Customer

FIBER QUITS,

OZZI WINS

You bought fiber to stop your cravings and fill you up. All you got was bloating and a 9pm snack attack you still can't shake.

Ozzi puts you back in control of your cravings, in ways plain fiber can only dream of.

OZZI IS

BUILT FOR CRAVINGS

Gut Health

Konjac supplies soluble fiber; butyrate supports gut-cell energy and signaling.

Blood Sugar

Allulose sweetens without the spike, while chromium and ursolic acid support blood sugar.

Natural GLP-1

Butyrate and allulose support GLP-1 and PYY, your fullness signals.

Appetite Control

Fiber fills you up while African mango supports leptin, your "I'm satisfied" signal.

Mother Nature's Best Crave Crushing Ingredients

6 Actives Selected For Your Snack-Time Routine.

Certified annually to NSF/ANSI 173 by Eurofins, with a Certificate of Analysis on every lot

Enjoy Ozzi Day Or Night

The Easiest Way To
Crush Cravings

Step 1: Pour

Just rip the easy-tear tab on your Ozzi, precisely dosed and easy to grab-and-go.

Step 2: Mix

Mix it with a spoon or frother for a few seconds to properly mix the flavor.

Step 3: Sip

Enjoy as quickly or slowly as you'd like.

What people are saying

4.2

Based on 321 reviews

70% would buy again 293 answers

Curbs hunger 3.7

Not at allCompletely

Customer photos

Most buyers say it helps with cravings and the urge to snack at night.

Some buyers mention the powder smells strong when the pouch is opened, which comes from butyrate, our most powerful ingredient.

Many buyers also say the flavors taste good once the powder is mixed and that the smell does not carry into the drink.

Summary by Ozzi, based on 318 reviews

Write a review

Showing 20 of 321 reviews

  1. Great taste really cyrnung the cravings at night especially !

    Cristina P. Verified buyer

  2. Nice flavor and easy to drink. Reduced my nighttime cravings somewhat.

    Matthew M. Verified buyer

  3. Ozzi worked very well to eliminate nighttime cravings after dinner, which is what I needed. I recommend it to anyone seeking a way to quash these cravings and prevent weight gain from it. Your body will be able to burn fat during the night and lose the extra fat accumulated from nighttime eating.

    Janet R. Verified buyer

  4. It takes the edge off: the rest is will power.

    Ruth B. Verified buyer

  5. All I can say is that it really does help. I used to be great at intermittent fasting but in recent years it just would be so tough in the evening not to eat. This is really helping to support a decrease in night time food cravings. I will be definitely purchasing again.

    Jonathan P. Verified buyer

  6. Weird initial smell that disappears when it’s mixed. I really like the taste of all three. I do think if I’m consistent, it helps me to not come home and snack a bunch

    Brian V. Verified buyer

  7. Great for late night snacking when my will power is tired

    Liam H. Verified buyer

  8. Good treat. I drink it twice a day: after lunch and after dinner. It helps distract from wanting candy. It does mellow hunger an bit until it’s meal time. All the flavors are very nice.

    Eric M. Verified buyer

  9. I love the flavor profile and it's definitely helped reduce my tummy bloat.

    Dan S. Verified buyer

  10. I take medication that gives me intense night time cravings, Ozzi has helped curb it

    Michael S. Verified buyer

  11. I mix it in with my Mango Green Iced Tea for a delicious afternoon boost. It satisfies my cravings until dinner.

    April H. Verified buyer

  12. I’ve started my journey almost two months now and my experience has been great! Lost 10 lb feeling good , my cravings has gone I’ve been on my journey for almost two months now, and it’s been great! I’ve lost 10 pounds and my cravings have gone away I must say great improvement

    Tino L. Verified buyer

  13. I just started taking Ozzi. But I'm so glad I have!! I bought one tart flavor (Cherry Limeade) and one sweet (Peach Elderflower).
    I'm glad for the heads-up about the slight funky scent, because that would have been a turn off if I wasn't ready.
    I notice the funkiness more in the limeade, but it's not terrible.
    And in the peach? Oh, it's just a lightly sweet drink. I enjoy it, and I'm glad to have this as a healthy choice tool.

    Jessica M. Verified buyer

  14. Love these products. Great flavors as well!

    Samuel B. Verified buyer

  15. I tried it the first day and cravings were about the same, then I did 2 with recommend hours in between and I could tell the difference in my cravings. I love there is no caffeine also

    Brenda J. Verified buyer

  16. Live my Ozzi!! Crushes my sweet cravings and tastes great!!

    Adam B. Verified buyer

  17. Definitely believe it curbs appetite at night.

    Sean B. Verified buyer

  18. My food noise is almost non-existent, especially at the end of the day and into the night. I can tell that something is happening differently because I am no longer craving sweets and I feel much more healthy throughout the day! I am an Ozzi believer!

    Shelley G. Verified buyer

  19. I’ve been trying my best to lose 20 to 25lbs and quite literally have had the hardest time and that’s because after I eat a meal I crave something sweet especially at night after I’m off work and once I saw the Ozzi product info I was curious. Mind you i actually started taking this around the time I was due for my monthly cycle which is when my cravings kick in the hardest! And to my surprise I noticed my cravings subsided and my brain was able to stop the noise of falling hard for the cravings even when I wasn’t hungry. I’ll continue to use this product and see how things go!! But I’m off to a great start!

    Aminah m.

  20. Really works! I can usually control my cravings until the night time hunger hits. I've been having 1 Ozzi drink after dinner and I have been able to stop my night time snacking which has finally made it possible to budge the scale back a bit. I'm def ordering more.

    Heather C. Verified buyer

Natural GLP-1, Answered

The questions people actually search. More on the FAQ page.

What is a natural GLP-1 supplement?

Yes, we describe Ozzi as a natural GLP-1 support supplement for cravings and food noise. Our ingredients were selected for research on fullness, glucose and gut signaling. That does not make the formula a prescription GLP-1 receptor agonist.

Explore the research

Do natural GLP-1 supplements actually work?

Ingredient studies include positive and mixed results. Check the tested form, amount and outcome. We have not completed a clinical trial of the finished Ozzi formula; our Research library explains how ingredient studies inform it.

Explore the research

Is there a natural alternative to GLP-1 medications?

A supplement can be a different option for a cravings routine, but our evidence does not establish Ozzi as a replacement for prescribed treatment or as having equivalent effects.

Explore the research

How do you stimulate GLP-1 naturally?

Human allulose and butyrate research includes hormone findings, with important differences in form, amount and population. Our ingredient page and research library explain those studies without assuming every ingredient directly raises GLP-1 in every person.

Explore the research

Does it have caffeine or stimulants?

Our drink is caffeine-free and stimulant-free. We designed it to fit an evening routine; that is not a claim that it treats sleep problems or can never affect an individual’s sleep.

Explore the research

Is Ozzi third-party tested?

Yes, and not the vague kind of "tested" the supplement industry likes. Ozzi is certified by Eurofins Healthcare Assurance to NSF/ANSI 173, the American National Standard for dietary supplements (certificate 20260428-0002, all five flavors). Every production lot also gets its own Certificate of Analysis: heavy metals, ingredient identity, and a full micro panel.

The certificate and the details live on our testing and certification page. One thing we'll say plainly: no supplement is "FDA approved," ours included. The FDA registers manufacturing facilities; it doesn't approve supplements, and brands implying otherwise are lying to you.

Can I take it with my medications?

Review the complete label with your prescribing clinician or pharmacist, especially when managing blood glucose or taking medicines whose absorption matters. Do not use this page to change a prescription.

Explore the research

Can I take it while pregnant or breastfeeding?

Ask your clinician before using it. We have not established the finished formula’s safety during pregnancy or breastfeeding.

Explore the research

How long until I notice a difference?

People’s experiences vary. We do not promise immediate fullness or a fixed hormonal timeline. Our 14-Day Ozzi Challenge gives you a defined period to judge cravings and food noise under the refund policy.

Explore the research

What if it doesn't work for me?

14-Day Ozzi Challenge: Take it for 14 straight days. If your cravings and food noise aren't quieter, we'll refund your first bag.

All three parts of that matter. It's 14 consecutive days of daily use, the refund applies if your cravings and food noise aren't quieter, and it covers your first bag.

There's nothing to send back, because we don't do returns. Keep the bag either way. Email help@heyozzi.com with your order number and confirm you used it daily for two weeks. Refunds are valid within 28 days of delivery.

What is the best GLP-1 supplement for weight management?

Compare the actual outcome studied, the ingredient form and amount, the current label and your goal. We make Ozzi for cravings and food noise; ingredient studies do not establish a predictable weight-loss result from our formula.

Explore the research

The research behind the ingredients

Explore the research that informed Ozzi’s six-ingredient formula—from post-meal blood-sugar responses to appetite and gut signaling.

Studies below tested individual ingredients or other formulations. Open a study to see the amount, population and findings.

Allulose — post-meal glucose and gut hormones

Allulose gives the drink its sweet taste and contributes to the formula’s blood-sugar and gut-hormone rationale. Human trials have found lower post-meal glucose responses at amounts close to the 8 g in one stick.

Effects of D-allulose on glucose tolerance and insulin response to a standard oral sucrose load: results of a prospective, randomized, crossover study.

2021 · Human trial

Franchi F, Yaranov DM, Rollini F, Rivas A, Rivas Rios J, Been L, Tani Y, Tokuda M, Iida T, Hayashi N, Angiolillo DJ, Mooradian AD. · BMJ open diabetes research & care

30 adults without diabetes; randomized crossover; 2.5, 5, 7.5 or 10 g with 50 g sucrose.

Allulose reduced the early post-drink glucose response in a dose-dependent pattern, with significant reductions at 7.5 and 10 g. The 10 g dose also reduced glucose and insulin excursions.

Read the original publication

Differential Modulation of Postprandial Glycemic, Incretin, and Satiety Responses by Low-Digestible Carbohydrates in Humans: An Exploratory Investigation.

2026 · Human trial

Noh J, Kim HR, Han J, Hwang H, Park J, Sa S, Atkinson F, Lau K, Byun S. · Nutrients

Two exploratory investigations, 10 participants each; 25 g carbohydrate testing and a separate 10 g allulose plus meal experiment.

In the meal experiment, 10 g allulose lowered post-meal glucose and insulin responses and increased circulating active GLP-1 compared with the meal alone. A statistically significant satiety improvement was reported for resistant maltodextrin, not allulose.

Read the original publication
Explore allulose in depth
Konjac — fiber viscosity and fullness

Konjac glucomannan is a soluble fiber that forms a viscous mixture with water. This physical property is why it is included in a formula designed around fullness.

In vitro gastric emptying characteristics of konjac glucomannan with different viscosity and its effects on appetite regulation.

2020 · Human trial

Shang L, Wang Y, Ren Y, Ai T, Zhou P, Hu L, Wang L, Li J, Li B. · Food & function

22 healthy adults; randomized single-blind crossover breakfasts with different viscosities; separate simulated gastric-emptying experiments.

Higher-viscosity breakfasts improved subjective hunger, fullness and desire-to-eat ratings and altered appetite-related hormone responses. Subsequent food intake changed only slightly.

Read the original publication

Safety and efficacy of glucomannan for weight loss in overweight and moderately obese adults.

2013 · Human trial

Keithley JK, Swanson B, Mikolaitis SL, DeMeo M, Zeller JM, Fogg L, Adamji J. · Journal of obesity

53 overweight or moderately obese adults; randomized trial; 1.33 g before each of three meals, with water, for eight weeks.

Glucomannan did not outperform placebo for weight, body composition, hunger, fullness, glucose or lipids. The investigators found the regimen generally tolerable.

Read the original publication
Explore konjac in depth
Butyrate — gut signaling and absorption

Butyrate is a short-chain fatty acid involved in gut-cell energy and signaling. Ozzi uses L-lysine butyrate to supply this postbiotic directly.

Effect of Butyrate and Inulin Supplementation on Glycemic Status, Lipid Profile and Glucagon-Like Peptide 1 Level in Patients with Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Trial.

2017 · Human trial

Roshanravan N, Mahdavi R, Alizadeh E, Jafarabadi MA, Hedayati M, Ghavami A, Alipour S, Alamdari NM, Barati M, Ostadrahimi A. · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

60 adults with type 2 diabetes; four groups; sodium butyrate, inulin, both or placebo for 45 days.

Sodium butyrate alone and the butyrate–inulin combination increased GLP-1 compared with placebo. Several other changes were confined to combination treatment or comparisons within a group.

Read the original publication

A Pharmacokinetic Comparison of Three Butyrate Products

2025 · Human pharmacokinetic trial

La Monica M, Kirby T, Hartshorn S, Gustat A, Grdic J, Sandrock J. · Journal of Exercise and Nutrition

10 healthy men; randomized crossover; lysine butyrate, sodium butyrate and tributyrin, each providing 786 mg butyric acid.

Lysine and sodium butyrate produced greater systemic exposure and earlier peak concentrations than tributyrin. The mean lysine-butyrate peak occurred at the first post-dose sample, 20 minutes.

Read the original publication
Explore butyrate in depth
African mango — extract research

African mango (Irvingia gabonensis) seed extracts have been studied for body measurements, glucose and metabolic markers. This research informed its inclusion in Ozzi’s multi-ingredient formula.

IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigation.

2009 · Human trial

Ngondi JL, Etoundi BC, Nyangono CB, Mbofung CM, Oben JE. · Lipids in health and disease

102 overweight or obese adults; randomized double-blind study; IGOB131 extract 150 mg twice daily before meals for 10 weeks.

IGOB131 improved weight, waist and body-fat measures as well as several metabolic markers compared with placebo. This is an important positive study of a specific African-mango seed extract.

Read the original publication

The Effects of Irvingia gabonensis Seed Extract Supplementation on Anthropometric and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis.

2020 · Systematic review

Lee J, Chung M, Fu Z, Choi J, Lee HJ. · Journal of the American College of Nutrition

Five randomized trials; four rated high risk of bias and one low risk.

Pooled weight and lipid results favored African-mango extracts, but trial quality weakened confidence. The one low-risk trial did not show statistically significant outcome differences.

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Ursolic acid — metabolic pathways

Ursolic acid is a plant compound studied for cellular energy pathways. It is one of two actives delivered together in Ozzi through Metabolex chromium polyursolate.

Ursolic acid increases energy expenditure through enhancing free fatty acid uptake and β-oxidation via an UCP3/AMPK-dependent pathway in skeletal muscle.

2015 · Animal and mechanism study

Chu X, He X, Shi Z, Li C, Guo F, Li S, Li Y, Na L, Sun C. · Molecular nutrition & food research

Diet-induced obese rats receiving 0.5% ursolic acid for six weeks, plus cell experiments.

Ursolic acid increased fatty-acid uptake and oxidation through an UCP3/AMPK-linked pathway. The animal experiments also showed lower weight and altered muscle lipid metabolism.

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The effects of ursolic acid on cardiometabolic risk factors: a systematic review and meta-analysis.

2024 · Systematic review

Rafiee P, Rasaei N, Amini MR, Rabiee R, Kalantar Z, Sheikhhossein F, Gholizadeh M, Hekmatdoost A. · Future cardiology

Six articles; adult doses 50.94–450 mg/day; search through February 2023.

The meta-analysis did not find significant pooled improvements in body size, body composition, glucose, insulin, blood pressure or the reported lipid outcomes. Human cardiometabolic efficacy remains uncertain despite favorable mechanisms and some small trials.

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Chromium — appetite and carbohydrate metabolism

Chromium is a trace mineral involved in carbohydrate metabolism. Ozzi supplies it with ursolic acid through Metabolex chromium polyursolate, while explaining the two actives separately.

Effects of chromium picolinate on food intake and satiety.

2008 · Human trial

Anton SD, Morrison CD, Cefalu WT, Martin CK, Coulon S, Geiselman P, Han H, White CL, Williamson DA. · Diabetes technology & therapeutics

42 overweight women reporting carbohydrate cravings; 1,000 mcg elemental chromium as picolinate daily versus placebo for eight weeks; 40 analyzed.

Chromium picolinate reduced measured food intake, hunger and fat cravings compared with placebo. The difference in weight change did not reach statistical significance.

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A meta-analysis of the effect of chromium supplementation on anthropometric indices of subjects with overweight or obesity.

2019 · Systematic review

Tsang C, Taghizadeh M, Aghabagheri E, Asemi Z, Jafarnejad S. · Clinical obesity

21 trials from 19 studies involving 1,316 overweight or obese participants.

Chromium was associated with small pooled reductions in weight, BMI and body-fat percentage; the average weight difference was about 0.75 kg. The authors questioned how clinically meaningful these changes were.

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